Plavix (Clopidogrel) 75 mg


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Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y₁₂ adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to.


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The way clopidogrel works is thought to be due to its active thiol metabolite, which inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor which indirectly inhibits platelet aggregation. This action is irreversible. By inhibiting platelet aggregation, blood flows more freely around the body.


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Clopidogrel (Plavix) Clopidogrel (Plavix®) is an antiplatelet drug you can take to prevent blood clots. It keeps platelets in your blood from coming together and making clots. You may need clopidogrel to prevent future issues if you had a heart attack, stroke or certain types of heart surgery. Additional Common Questions.


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Generic Name Clopidogrel DrugBank Accession Number DB00758 Background. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. 3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or.


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Multidrug therapy increases the risk for drug-drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y 12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in.


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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.


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It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).


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Clopidogrel slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot. The clot can stop blood flowing to the heart.


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Clopidogrel remains the most widely prescribed P2Y 12 inhibitor worldwide, largely related to clinician familiarity and affordability. Given frequent co-administration of clopidogrel and PPI therapy, their common hepatic metabolism, and the consequences of suboptimal therapeutic effects, clarifying a possible adverse pharmacological interaction.


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The DDI profiles of clopidogrel have been reviewed by Egan et al, Shah et al, Siller-Matula et al and Scott et al.7-10 However, these authors only addressed the circumstances under which DDIs occurred when clopidogrel was the object drug or focused on combination therapy with clopidogrel and special classes of medications, such as.


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Clopidogrel Interactions. There are 249 drugs known to interact with clopidogrel, along with 3 disease interactions. Of the total drug interactions, 64 are major, 168 are moderate, and 17 are minor.


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Clopidogrel oral tablet is a prescription medication used to prevent heart attack or stroke. It works by preventing blood clots, which it does by keeping platelets in your blood from sticking.


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Plavix is a P2Y12 platelet inhibitor indicated for: Acute coronary syndrome. For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), Plavix has been shown to reduce the rate of myocardial infarction (MI) and stroke. (1.1)


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Defibrotide. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab. Aceclofenac. Acemetacin. Alfentanil.


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Plavix (clopidogrel bisulfate) is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Chemically it is methyl (+)-(S)-α (2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H.


Plavix (Clopidogrel) 75 mg

Key takeaways: Clopidogrel is a medication that prevents blood clots from forming. This can lower the risk of heart attack and stroke. Medications like proton pump inhibitors (PPIs), fluoxetine (Prozac), and fluconazole (Diflucan) can make clopidogrel less effective. Grapefruit juice can also make clopidogrel less effective.

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